Fig. 1: Expression of Ref-1 and p-STAT3 in tissue from patient samples and in mice that have conditional ablation in the Schwann cells of Nf1−/−; Arf+/− and Nf1–/–; Arf−/−. | British Journal of Cancer

Fig. 1: Expression of Ref-1 and p-STAT3 in tissue from patient samples and in mice that have conditional ablation in the Schwann cells of Nf1−/−; Arf+/− and Nf1–/–; Arf−/−.

From: Exploring transcriptional regulators Ref-1 and STAT3 as therapeutic targets in malignant peripheral nerve sheath tumours

Fig. 1

IHC for p-STAT3 and Ref-1 levels in PN (n = 4), ANNUBP (n = 4) and MPNST patient samples (n = 14) with representative IHC images in (a) and quantitation by Aperio for pixel positivity (b, c, *P < 0.05) where the large circles with the same colour correspond to a sample from the same patient. (d) pSTAT3 and Ref-1 IHC images for MPNST patient sample and its corresponding PDX. Tissue from genetically engineered mouse models (e) was analysed by HALO for positive cells (f, g). For panels a and e, representative pictures are shown (e, n = 4, ***P < 0.001, ****P < 0.0001). Scale bar: 100 or 200 μm as noted.

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