Fig. 4: ETNK2 knockout reduces the growth and hepatic metastasis of GC cells in a mouse xenograft model. | British Journal of Cancer

Fig. 4: ETNK2 knockout reduces the growth and hepatic metastasis of GC cells in a mouse xenograft model.

From: Hepatic metastasis of gastric cancer is associated with enhanced expression of ethanolamine kinase 2 via the p53–Bcl-2 intrinsic apoptosis pathway

Fig. 4

a Images of mice and excised tumours (upper) and quantification of tumour volumes (lower) after subcutaneous injection of mice with untransfected or ETNK2 KO MKN1 cells. b Results of immunohistochemical analysis of ETNK2, cleaved caspase-3, cleaved PARP, and HIF-1a in subcutaneous tumours formed by parental MKN1 cells and ETNK2 KO cells. c In vivo bioluminescent imaging of hepatic metastases (upper) and quantification of the bioluminescence signal in mice injected with untransfected or ETNK2 KO MKN1 cells (lower). d MRI and macroscopic image of the liver in mice injected with untransfected or ETNK2 KO MKN1 cells. *P < 0.005. Data are presented as the mean ± standard deviation.

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