Fig. 6: Validation of the correlation between S100P and SLC2A5 in clinical CRC samples. | British Journal of Cancer

Fig. 6: Validation of the correlation between S100P and SLC2A5 in clinical CRC samples.

From: S100P contributes to promoter demethylation and transcriptional activation of SLC2A5 to promote metastasis in colorectal cancer

Fig. 6

a Representative IHC images of S100P and SLC2A5 expression in TMA. Scale bar, 100 μm (10×), 50 μm (20×). b The stacked histogram shows the expression distribution of S100P and SLC2A5 in 142 patients with CRC. c Correlation analysis shows a positive correlation between S100P and SLC2A5 expression in primary CRC (n = 142), based on Pearson χ2 test. d Schematic diagram summarising the mechanism in this study, namely, nuclear S100P reduces the methylation levels of SLC2A5 promoter by binding to the SLC2A5 promoter, thereby enhancing the transcriptional activity of SLC2A5, followed by promoting CRC cell invasion and metastasis via inducing EMT.

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