Fig. 1: 5-Aminosalicylic acid inhibits the growth of human colonic adenoma cells as well as carcinoma cell lines in two-dimensional culture. | British Journal of Cancer

Fig. 1: 5-Aminosalicylic acid inhibits the growth of human colonic adenoma cells as well as carcinoma cell lines in two-dimensional culture.

From: 5-Aminosalicylic acid inhibits stem cell function in human adenoma-derived cells: implications for chemoprophylaxis in colorectal tumorigenesis

Fig. 1

a Graphs show attached cell yield and the number of floating cells as a proportion of total cell yield of three adenoma-derived cell lines (PC/AA/C1, S/AN/C1 and S/RG/C2), left, transformed adenocarcinoma cells (PC/AA/C1/SB10) and two CRC-derived cell lines (LS174T and SW620), right, 24, 48 and 72 h after treatment with 20 and 40 mM 5-ASA. Mean ± SEM; n = 3. One-way ANOVA with Bonferroni post-test, *p < 0.05; **p < 0.01; ***p < 0.001. b Graphs show attached cell yield and percentage of floating cells of (i) PC/AA/C1 and (ii) S/RG/C2; after treatment with 40 mM 5-ASA and 10 µM Q-VD-Oph or DMSO, cells were harvested and counted at 72 h. Mean ± SEM; n = 3. One-way ANOVA with Bonferroni post-test, **p < 0.01; ***p < 0.001.

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