Fig. 4: Summary of mechanisms through which obesity promotes tumorigenesis.
From: Targeting obesity-related dysfunction in hormonally driven cancers
HIF1α hypoxia- inducible factor 1- alpha, VEGF vascular endothelial growth factor, TNFα tumor necrosis factor alpha, IL-1β interleukin 1 beta, IL- 6 interleukin 6, COX-2 cyclooxygenase isoenzyme 2, IGFR- insuline-like growth factor receptor, JAK-STAT Janus kinases-signal transducer and activtor of transcription proteins, MAPK mitogen-activated protein kinase.
