Table 1 Associations of genetic risk scores for cigarette smoke exposure-related traits with breast cancer risk: results from Mendelian randomisation analysis.

From: Mendelian randomisation study of smoking exposure in relation to breast cancer risk

 

CPD

LSI

No. of cases/controls

ORd

95% CI

P

No. of cases/controls

ORe

95% CI

P

Model 1a

26,147/26,072

1.02

0.78–1.19

0.85

108,420/87,681

1.18

1.07–1.30

1.1 × 10−3

Model 2b

7360/7168

0.98

0.74–1.33

0.95

17,936/16,654

1.24

1.06–1.45

6.0 × 10−3

Model 3c

2892/2754

0.66

0.36–1.19

0.16

7716/7028

1.13

0.86–1.49

0.39

  1. No. number, CPD cigarettes per day, LSI lifetime smoking index, OR odds ratio per year, CI confidence interval, P P value, BMI body mass index.
  2. aAdjusted for age, sex and top ten PCs. P value for heterogeneity between iCOGS and OncoArray data of cigarettes per day and lifetime smoking index are 0.60, 0.09, respectively; bin addition to adjustment of Model 1, additionally adjusted for ever breastfeeding, postmenopausal status, age at menopause, BMI, age at first live birth, parity and education level. P value for heterogeneity between iCOGS and OncoArray data of cigarettes per day and lifetime smoking index are 0.96, 0.37, respectively; cin addition to adjustment of Model 2, additionally adjusted for alcohol assumption (glasses per day) P value for heterogeneity between iCOGS and OncoArray data of cigarettes per day and lifetime smoking index are 0.80, 0.66 respectively; dOR per pack of cigarettes per day; eOR per standard deviation.
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