Fig. 4: Effects of various ROCK inhibitors on 4599 and 4599.NC melanoma cell survival.
From: A preclinical pipeline to evaluate migrastatics as therapeutic agents in metastatic melanoma
a Chemical structures and reported IC50 values for the listed compounds. Tabled IC50 values (nM) were previously reported: H115263; AT1314864; Y2763265; and GSK269962.66 b–e Comparative cell survival assays in the presence of different concentrations of the indicated ROCK inhibitors revealed no differences between 4599 and 4599.NC cells; N = 3, error bars represent SD. EC50 including 95% confidence intervals [lower;higher end of range] were calculated using the variable slope dose-response model using Graphpad Prism v7. Grey shades depict 95% confidence intervals for 4599 cells (black circles/grey non-linear fit line) and red dotted lines depict 95% confidence intervals for 4599.NC cells (red squares/red non-linear fit line).
