Table 3 Associations between circulating biomarkers of inflammation and CRC-specific mortality according to time of follow-up since blood draw, overall (n = 302) and among those with CRP ≤ 10 mg/L (n = 244).
Markersa | HR (95% CI)b | ||
|---|---|---|---|
<1 year | 1–3 years | >3 years | |
All (n = 302) | |||
No. of deaths/total | 17/302 | 18/280 | 18/258 |
CRP (mg/L) | 1.75 (1.2–2.56) | 1.31 (0.9–1.93) | 1.22 (0.83–1.79) |
IL-6 (pg/mL) | 5.01 (2.92–8.59) | 2.66 (1.52–4.66) | 2.03 (1.1–3.72) |
MCP-1 (pg/mL) | 3.78 (1.41–10.08) | 1.14 (0.29–4.49) | 1.17 (0.31–4.45) |
Adiponectin (μg/mL) | 3.16 (1.27–7.86) | 1.83 (0.77–4.35) | 0.57 (0.23–1.39) |
Leptin (ng/mL) | 0.44 (0.29–0.68) | 1.04 (0.71–1.53) | 0.93 (0.63–1.36) |
CRP ≤ 10 mg/L (n = 244) | |||
N deaths/Total | 8/244 | 12/232 | 14/216 |
CRP (mg/L) | 0.65 (0.34–1.25) | 0.97 (0.53–1.77) | 0.99 (0.57–1.72) |
IL-6 (pg/mL) | 6.23 (2.97–13.04) | 3.99 (1.76–9.09) | 1.74 (0.69–4.34) |
MCP-1 (pg/mL) | 5.53 (0.9–34.16) | 1.86 (0.32–10.64) | 0.54 (0.09–3.09) |
Adiponectin (μg/mL) | 5.45 (1.5–19.83) | 2.29 (0.79–6.65) | 0.84 (0.31–2.28) |
Leptin (ng/mL) | 0.45 (0.23–0.86) | 0.96 (0.58–1.6) | 0.9 (0.57–1.44) |
