Fig. 4: Refined CIN classification and association with response to neoadjuvant CTx and patients survival in the tumour biopsy cohort before CTx.

The response to neoadjuvant CTx (a, c) and association with survival (b, d) is shown for patients with tumour biopsies before CTx in relation to the respective CIN-subgroup. CIN chromosomal instability, TRG tumour regression grade, 1Chi-squared test (overall). 2Cox’s regression.