Fig. 2: Progression Free Survival.

a Time to PFS event or censor for all dosed patients. PFS event is confirmed disease progression or death before documented treatment discontinuation or the start of a new anti-MM treatment. Y-axis labels indicate which drugs each patient was refractory to (V bortezomib, K carfilzomib, R lenalidomide, P pomalidomide, D daratumumab) and whether they had high-risk cytogenetics (* = Yes), defined as any of del(17p), t(4;14), t(14;16) or gain 1q at initial diagnosis or screening. TX toxicity to study drug, AE adverse event, CP disease progression (clinical progression), WC withdrawal of consent, OT other, event PFS event. b Kaplan-Meier analysis of progression-free survival (PFS) for all dosed patients (n = 32). Median PFS for all patients was 15.0 months (95% CI, 12.0–NE) and 23.7 months (95% CI, 3.9–NE) patients with triple-class refractory MM.