Fig. 3: Comparison of radiomics profiles between KEM, TCGA and HH cohorts.

a Proportion of RPV low, medium and high subgroups in HH, TCGA and KEM cohort; Fishers exact test KEM vs HH (P = 0.00253), KEM vs TCGA (P = 0.025). b Boxplot indicating the volume of the primary tumour segmented from CT scans in HH, TCGA and KEM cohorts; size of the segmented tumours from KEM cohort was significantly smaller than those of HH (P = 2.102e-06; t test) or TCGA (P = 0.00943; t test) cohorts. c Principal component analysis showing the variation of radiomics profile for cases in HH, TCGA and KEM cohorts. The radiomics profile from HH and TCGA cohorts closely cluster together (P > 0.05, t test) and are shifted from the radiomics profile for the KEM cohort (P < 0.0001, t test).