Fig. 1: Frequency and landscape of germline CDH1 variants.

a Frequency of P/LP germline variants in CDH1 in each of the seven cancer types. The numbers above each bar indicate the total number of patients tested for each cancer type; the number within each box indicates the number of P/LP variants. Y axis is frequency. b Landscape of P/LP germline variants in CDH1 in 212,944 patients with cancer. The variants are labeled with carrier counts and coloured by their respective carriers’ ancestry (Caucasian: blue, African American: red, Asian: green, Ashkenazi Jewish: black, non-white Hispanic: orange) for breast cancer, gastric cancer, and colorectal cancer. c Frequency of P/LP germline variants in CDH1 in each of the five ethnicities in the gnomAD v3 cohort. The numbers above each bar indicate the total number of subjects assessed by sequencing; the number within each box indicates the number of P/LP variants.