Fig. 1: Probability of long-term disease free according to the tumor intrinsic chemosensitivity.
From: Low probability of disease cure in advanced ovarian carcinomas before the PARP inhibitor era
Multivariate logistic regression model of the probability of long-term disease-free (LDF) > 5 years according to: a disease stage and standardised KELIM in the “adjuvant dataset”; b to disease-risk group (based the disease stage and the completeness of interval debulking surgery) and to standardised KELIM in the “neoadjuvant dataset” (Netherlands Cancer Registry). For example, for a patient with a Stage III disease, the probability of LDF is estimated at 7.0% in the case of complete IDS & favourable std KELIM at 1.5 days−1; 3.0% in the case of complete IDS & unfavourable std KELIM at 0.5 days−1; 2.0% in the case of incomplete IDS & favourable std KELIM at 1.5 days−1; and 1.0% in the case of incomplete IDS & favourable std KELIM at 0.5 days−1. Dashed black line: cut-off for unfavourable KELIM < 1; or favourable KELIM ≥ 1. LCR Long complete remission.
