Fig. 4: CMS4 Peritoneal Metastases uniformly express high levels of FAP. | British Journal of Cancer

Fig. 4: CMS4 Peritoneal Metastases uniformly express high levels of FAP.

From: Fibroblast activation protein identifies Consensus Molecular Subtype 4 in colorectal cancer and allows its detection by 68Ga-FAPI-PET imaging

Fig. 4

a Dot plot showing relative FAP expression levels in primary CRC tumours in the TCGA cohort (n = 592) versus primary tumours with peritoneal involvement (n = 35) and the peritoneal metastases derived from them (n = 59). b Dot plot showing FAP expression levels in peritoneal metastases and their matched primary tumours. CMS subtypes are colour-coded. Tissue type is annotated by shape. c Scatter plot showing the correlation of FAP mRNA levels with CMS4 probabilities of all tumours in the primary tumour/peritoneal metastasis cohort. d Immunohistochemistry for FAP expression in peritoneal metastasis. See Supplementary Fig. S5 for a comprehensive overview of FAP protein expression in peritoneal metastases. e Boxplot of FAP expression quantification on IHC slides of colorectal liver metastasis (CRLM, n = 21) and peritoneal metastasis (PM, n = 19). FAP expression is measured as the number of FAP-positive cells and corrected for tumour size using an EpCAM staining of the sequential slide. f Boxplot of the percentage of FAP-positive stromal cells of colorectal liver metastasis (CRLM, n = 21) and peritoneal metastasis (PM, n = 19). g Boxplot of the percentage of FAP-positive tumour cells of colorectal liver metastasis (CRLM, n = 21) and peritoneal metastasis (PM, n = 19).

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