Table 2 Association of plasma glucose related factors and insulin with cancer occurrence over 30-year.a

From: Cancer and its predictors in Chinese adults with newly diagnosed diabetes and impaired glucose tolerance (IGT): a 30-year follow-up of the Da Qing IGT and Diabetes Study

 

Hazard ratio

95% Confidence interval

P value

In all participants(n = 1697)

  Fasting glucose (mmol/L)

1.01

0.96–1.07

0.69

  Glucose at 1 h (mmol/L)

1.03

1.01–1.06

0.02

  Glucose at 2 h (mmol/L)

1.03

1.004–1.06

0.02

  Glucose at 1 h-Fasting glucose(mmol/L)

1.06

1.02–1.11

0.003

  Glucose at 2 h-Fasting glucose (mmol/L)

1.06

1.02–1.10

0.002

In non-diabetes participantsb(n = 1085)

  Fasting glucose (mmol/L)

0.91

0.77–1.15

0.54

  Glucose at 1 h (mmol/L)

1.03

0.99–1.11

0.25

  Glucose at 2 h (mmol/L)

1.05

0.99–1.14

0.17

  Glucose at 1 h-Fasting glucose (mmol/L)

1.05

1.001–1.13

0.11

  Glucose at 2 h-Fasting glucose (mmol/L)

1.09

1.01–1.19

0.0049

  Diabetes-free time (10 years)

0.75

0.64–0.87

0.0002

In participants with IGT(n = 575)

   

  Fasting glucose (mmol/L)

0.89

0.67–1.17

0.40

  Glucose at 1 h (mmol/L)

1.01

0.91–1.11

0.90

  Glucose at 2 h (mmol/L)

1.07

0.85–1.34

0.59

  Glucose at 1 h-Fasting glucose (mmol/L)

1.03

0.92–1.15

0.62

  Glucose at 2 h-Fasting glucose (mmol/L)

1.13

0.92–1.39

0.26

  Progression to diabetes (yes = 1)c

2.28

1.24–4.20

0.008

  Fasting insulin (mu/L) (n = 302)d

1.47

0.87–2.49

0.15

  Insulin AUC (mu/L) (n = 302)d

2.03

1.08–3.81

0.03

  1. Insulin AUC insulin area under the curve, IGT impaired glucose tolerance, NDM newly diagnosed diabetes, NGT normal glucose tolerance, Diabetes-free time number of years from entry to time of onset of diabetes.
  2. aAge, sex, smoking status, systolic blood pressure and body mass index adjusted.
  3. bNon-diabetes participants included people with IGT and NGT.
  4. cProgression to diabetes was taken as a time-dependent variable in COX model.
  5. dLog transformed value.
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