Table 4 Predictive effects of progression to diabetes and one-SD increase in insulin resistance and insulin level at baseline on risk of cancer in participants with IGT over 30 years.

From: Cancer and its predictors in Chinese adults with newly diagnosed diabetes and impaired glucose tolerance (IGT): a 30-year follow-up of the Da Qing IGT and Diabetes Study

 

HR

95% CI

P value

Model 1

   

  Age (9.3years)

2.89

1.87–4.46

<0.0001

  Sex (male = 1)

1.43

0.69–2.97

0.34

  Smoking status (yes = 1)

1.50

0.75–3.00

0.25

  BMI (3.8 kg/M2)

1.40

0.96–2.06

0.08

  SBP (23 mmHg)

1.22

0.83–1.81

0.32

  Intervention (yes = 1)

0.88

0.40–1.94

0.76

  Progressed to diabetes (yes = 1)

2.30

1.54–3.45

<0.0001

  Matsuda_IRa (170 mu.mmol/l)

1.41

1.06–1.87

0.02

Model 2

   

  Age (9.3 years)

2.73

1.85–4.03

<0.0001

  Sex (male = 1)

1.13

0.57–2.25

0.72

  Smoking status (yes = 1)

1.87

0.96–3.66

0.07

  BMI (3.8 kg/M2)

1.44

1.02–2.03

0.04

  SBP (23 mmHg)

1.31

0.94–1.82

0.11

  Intervention (yes = 1)

1.03

0.50–2.13

0.93

  Progressed to diabetes (yes = 1)

1.87

1.28–2.72

0.001

 Homa_IRb (4.34 mu/l)

1.15

0.85–1.53

0.37

Model 3

   

  Age (9.3 years)

2.91

1.89–4.50

<0.0001

  Sex (male = 1)

1.43

0.69–2.96

0.33

  Smoking status (yes = 1)

1.56

0.78–3.10

0.21

  BMI (3.8 kg/M2)

1.40

0.97–2.02

0.07

  SBP (23 mmHg)

1.28

0.87–1.88

0.21

  Intervention (yes = 1)

0.88

0.40–1.92

0.74

  Progressed to diabetes (yes = 1)

2.18

1.47–3.26

0.0001

  Insulin area** (103 mu/l)

1.39

1.05–1.84

0.02

  1. CI confidence interval, HR hazard ratio, IGT impaired glucose tolerance, SD standard deviation.
  2. aMatsud_IR was an insulin resistance index; Insulin AUC, the insulin area under curve in OGTT.
  3. bOnly participants with IGT having insulin determination were included (n = 307).
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