Table 2 Unadjusted and adjusted annual and monthly pairwise Incidence Rate Ratios (IRRs) (Bonferroni corrected 95% confidence intervals) comparisons of 2020 and 2019 for female breast, colorectal and non-small cell lung cancer.

From: Impact of the SARS-CoV-2 pandemic on female breast, colorectal and non-small cell lung cancer incidence, stage and healthcare pathway to diagnosis during 2020 in Wales, UK, using a national cancer clinical record system

 

Female breast cancer

Colorectal cancer

Non-small-cell lung cancer

 

Unadjusted

Adjusted

Unadjusted

Adjusted

Unadjusted

Adjusted

 

IRR

95% CI

IRR

95% CI

IRR

95% CI

IRR

95% CI

IRR

95% CI

IRR

95% CI

Year

0.81

0.76, 0.86***

0.79

0.74, 0.84***

0.80

0.79, 0.81***

0.80

0.75, 0.85***

0.91

0.90, 0.92***

0.89

0.83, 0.95***

Month

            

 January

1.10

1.03, 1.18***

1.12

0.77, 1.61

0.87

0.81, 0.93***

0.75

0.40, 1.63

1.10

1.03, 1.17***

1.02

0.69, 1.48

 February

1.00

0.93, 1.10

1.03

0.69, 1.53

0.98

0.92, 1.06

0.97

0.44, 2.12

1.05

0.98, 1.13

1.03

0.70, 1.54

 March

1.10

1.02, 1.17***

1.12

0.75, 1.65

1.05

0.98, 1.12

1.08

0.60, 1.94

0.94

0.87, 1.01

0.95

0.63, 1.42

 April

0.58

0.50, 0.59***

0.62

0.38, 0.98*

0.40

0.37, 0.44***

0.43

0.21, 0.87**

0.73

0.68, 0.80***

0.75

0.48, 1.19

 May

0.51

0.48, 0.55***

0.49

0.32, 0.76***

0.55

0.51, 0.60***

0.57

0.28, 0.98*

0.73

0.67, 0.78***

0.71

0.46, 1.11

 June

0.71

0.66, 0.77***

0.71

0.46, 1.01

0.90

0.83, 0.96***

1.02

0.42, 2.48

0.92

0.85, 0.99**

0.90

0.59, 1.37

 July

0.60

0.53, 0.61***

0.56

0.38, 0.83***

0.88

0.82, 0.94***

0.91

0.45, 1.84

0.99

0.92, 1.06

0.99

0.67, 1.46

 August

0.53

0.49, 0.58***

0.51

0.32, 0.82***

0.79

0.73, 0.85***

0.77

0.41, 1.45

0.84

0.78, 0.90***

0.80

0.52, 1.22

 September

0.87

0.91, 1.04

0.95

0.65, 1.39

0.79

0.74, 0.85***

0.92

0.51, 1.62

1.21

1.13, 1.31***

1.14

0.75, 1.73

 October

0.73

0.69, 0.78***

0.73

0.50, 1.07

0.82

0.76, 0.88***

0.86

0.42, 1.76

0.75

0.70, 0.81***

0.75

0.49, 1.14

 November

1.14

1.07, 1.22***

1.16

0.80, 1.69

0.98

0.91, 1.05

0.94

0.52, 1.73

0.86

0.77, 0.93***

0.82

0.53, 1.27

 December

0.93

0.87, 0.99*

0.96

0.64, 1.43

0.90

0.84, 0.97***

0.92

0.46, 1.82

0.91

0.84, 0.98**

0.88

0.56, 1.40

Stage at diagnosis

            

 Stage I

0.58

0.49, 0.70***

0.57

0.48, 0.70***

0.77

0.58, 1.03

0.72

0.53, 0.97*

–

–

–

–

 Stage II

0.79

0.68, 0.93***

0.78

0.67, 0.93***

0.80

0.63, 1.03

0.76

0.59, 0.98*

–

–

–

–

 Stage III

0.82

0.61, 1.11

0.85

0.62, 1.16

0.73

0.62, 0.87***

0.71

0.60, 0.84***

–

–

–

–

 Stage IV

0.71

0.33, 1.52

0.62

0.28, 1.37

0.77

0.62, 0.95**

0.72

0.58, 0.90***

–

–

–

–

 Unknown

1.56

1.22, 1.98***

1.56

1.21, 2.00***

4.68

2.47, 8.87***

5.06

2.61, 9.80***

–

–

–

–

Healthcare pathway to diagnosis

            

 Screening

0.52

0.43, 0.63***

0.56

0.46, 0.69***

0.90

0.67, 1.22

0.82

0.60, 1.12

    

 GP urgent

1.02

0.89, 1.18

1.01

0.88, 1.17

0.84

0.73, 0.98**

0.81

0.69, 0.95***

0.81

0.67, 0.97**

0.78

0.65, 0.94***

 Emergency

0.89

0.42, 1.87

1.00

0.47, 2.16

0.92

0.74, 1.56

0.92

0.73, 1.16

0.88

0.73, 1.06

0.96

0.79, 1.16

 From in-patient

1.20

0.76, 1.89

1.33

0.82, 2.15

0.72

0.49, 1.07

0.66

0.45, 0.98*

0.94

0.70, 1.25

0.97

0.72, 1.30

 From out-patient

0.84

0.57, 1.36

0.78

0.48, 1.27

0.95

0.52, 1.71

0.96

0.53, 1.75

1.08

0.78, 1.50

0.93

0.67, 1.30

 Other

0.39

0.17, 0.86***

0.47

0.21, 1.11

0.98

0.47, 2.03

0.87

0.41, 1.82

1.16

0.65, 2.08

1.08

0.60, 1.96

 Not known

N/A

N/A

N/A

N/A

0.86

0.44, 1.68

0.93

0.46, 1.86

0.89

0.61, 1.30

0.91

0.62, 1.33

Sex

            

 Male

–

–

–

–

0.84

0.75, 0.94***

0.85

0.76, 0.95**

0.83

0.81, 0.85***

0.88

0.86, 0.89***

 Female

0.82

0.77, 0.87***

0.83

0.74, 0.92**

0.73

0.65, 0.84***

0.73

0.64, 0.84***

0.94

0.92, 0.96***

0.96

0.94, 0.98***

Age

            

 Under 50

0.99

0.78, 1.26

0.94

0.73, 1.20

0.92

0.62, 1.37

0.95

0.63, 1.44

1.00

0.90, 1.13

1.05

0.94, 1.18

 50–69

0.76

0.66, 0.87***

0.77

0.67, 0.88***

0.79

0.67, 0.93***

0.81

0.68, 0.96**

0.99

0.96, 1.02

1.00

0.96, 1.03

 70–79

0.82

0.67, 1.01

0.83

0.67, 1.01

0.74

0.63, 0.88***

0.78

0.65, 0.93***

0.90

0.88, 0.92***

0.93

0.91, 0.96***

 80+

0.81

0.64, 1.03

0.79

0.62, 1.01

0.77

0.63, 0.93**

0.77

0.63, 0.94

0.76

0.73, 0.78***

0.79

0.76, 0.81***

WIMD income

            

 1—least deprived

0.78

0.63, 0.97**

0.74

0.60, 0.92***

0.75

0.60, 0.94**

0.76

0.61, 0.96**

0.86

0.82, 0.90***

0.87

0.82, 0.91***

 2

0.71

0.57, 0.89***

0.75

0.60, 0.94**

0.74

0.59, 0.93**

0.77

0.62, 0.97**

0.89

0.85, 0.93***

0.86

0.83, 0.90

 3

0.76

0.61, 0.95**

0.76

0.61, 0.94**

0.77

0.61, 0.98*

0.80

0.63, 1.01

0.87

0.84, 0.91***

0.96

0.92, 1.00

 4

0.93

0.74, 1.16

0.97

0.77, 1.22

0.80

0.63, 1.00

0.80

0.64, 1.01

0.92

0.89, 0.96***

0.92

0.88, 0.95***

 5— most deprived

0.90

0.70, 1.51

0.86

0.67, 1.10

0.83

0.64, 1.07

0.87

0.67, 1.12

0.95

0.91, 0.98***

0.95

0.92, 0.99**

  1. Adjusted for age group (under 50, 50–69, 70–79, 80+), sex (for colorectal and NSCL cancers) and area-level income deprivation quintiles (WIMD).
  2. *p < 0.05.
  3. **p < 0.01.
  4. ***p < 0.001.
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