Fig. 1: MBD3 is highly expressed in HCC and indicates poor prognosis. | British Journal of Cancer

Fig. 1: MBD3 is highly expressed in HCC and indicates poor prognosis.

From: MBD3 promotes hepatocellular carcinoma progression and metastasis through negative regulation of tumour suppressor TFPI2

Fig. 1

a Representative IHC staining of MBD3 in HCC and adjacent tissues, with normal IgG as a negative control. Scale bars: 500 μm and 50 μm. b Left panel: The MBD3 scores of each liver cancer and adjacent liver tissue. Right panel: The MBD3 scores of HCC and adjacent liver tissues (n = 227), expressed as mean ± SD. c Analysis of MBD3 mRNA levels in normal liver tissue (n = 160) and HCC (n = 369) from the TCGA database. d, e Kaplan–Meier curves of overall and diseases-free survival of 227 HCC samples we collected (d) and 331 HCC samples from the TCGA database (e), stratified by MBD3 expression. b, c Mann–Whitney U test; d, e log-rank test. ***P < 0.001.

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