Fig. 3: Tumour suppressor TFPI2 is the downstream target gene regulated by MBD3. | British Journal of Cancer

Fig. 3: Tumour suppressor TFPI2 is the downstream target gene regulated by MBD3.

From: MBD3 promotes hepatocellular carcinoma progression and metastasis through negative regulation of tumour suppressor TFPI2

Fig. 3

a Huh7 cells stably transfected with shMBD3 and control were analysed by the whole-transcriptome sequencing (RNA-seq). All the altered genes after MBD3 knockdown are shown (1.5-fold, P < 0.05). b GO and KEGG enrichment analysis of the above differential genes were performed by DAVID database, and top 7 term regulated by MBD3 in biologic process, cellular component, molecular function as well as KEGG pathway were shown. c The heatmap of differential genes in the serine endopeptidase inhibitor family caused by MBD3 inhibition in Huh7 cells. d Western blotting of MBD3 and TFPI2 in the indicated stable cell lines.

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