Fig. 4: MBD3 promotes the angiogenesis of HCC tissues by inhibiting TFPI2. | British Journal of Cancer

Fig. 4: MBD3 promotes the angiogenesis of HCC tissues by inhibiting TFPI2.

From: MBD3 promotes hepatocellular carcinoma progression and metastasis through negative regulation of tumour suppressor TFPI2

Fig. 4

a Representative IHC staining of MBD3, TFPI2 and CD34 in different parts of serial sections of HCC. Scale bars: 100 μm and 1 mm. b Representative IHC staining of MBD3, TFPI2 and CD34 in serial sections of 140 HCC cases. Scale bar: 500 μm. c Boxplot showing TFPI2 expression (left panel) and the percentage of TFPI2–positive tumours (right panel) in 140 HCC samples. The samples were divided into three groups according to MBD3 expression scores in the tumours, representing low (scores 0–4), medium (scores 5–8) and high (scores 9–12) expression of MBD3. d The relationship of CD34-MVD and TFPI2 in three groups of samples divided based on TFPI2 expression scores as that of MBD3 in c. Data were analysed by one-way ANOVA test (c (left panel) and d) and Pearson’s χ2 test (c (right penal)).

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