Fig. 7: Schematic representation of MBD3 promoting HCC progression and metastasis by inhibiting TFPI2. | British Journal of Cancer

Fig. 7: Schematic representation of MBD3 promoting HCC progression and metastasis by inhibiting TFPI2.

From: MBD3 promotes hepatocellular carcinoma progression and metastasis through negative regulation of tumour suppressor TFPI2

Fig. 7

Up panel: When MBD3 is low expressed in HCC, tumour suppressor TFPI2 can be normally expressed and inhibit the proliferation, angiogenesis and metastasis of HCC. Down panel: When MBD3 is high expressed in HCC, it can recruit CHD4 and HDAC1 to form NuRD complex and bind to the promoter of TFPI2, inducing TFPI2 gene inhibition, and then indirectly release the proliferation, angiogenesis and metastasis of HCC.

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