Table 2 Correlation between clinicopathological variables and FCR.

From: Regulatory T cells induce a suppressive immune milieu and promote lymph node metastasis in intrahepatic cholangiocarcinoma

Variables

FCR low

FCR high

P-value

(N = 44, 72.1%)

(N = 17, 27.9%)

Age median, (range)

67 (45–85)

67.5 (45–85)

67.0 (51–83)

0.750b

Sex

Female (N = 27)

19 (70.4)

8 (29.6)

1

Male (N = 34)

25 (73.5)

9 (26.5)

HBs-Ag

Positive (N = 7)

4 (57.1)

3 (42.9)

0.393

Negative (N = 53)

39 (73.6)

14 (26.4)

HCV-Ab

Positive (N = 5)

4 (80.0)

1 (20.0)

1

Negative (N = 55)

39 (70.9)

16 (29.1)

Morphology

MF (N = 39)

29 (74.4)

10 (25.6)

0.767

MF + PI (N = 22)

15 (68.2)

7 (31.8)

Differentiation

Well (N = 9)

8 (88.9)

1 (11.1)

0.423

Moderate (N = 39)

25 (64.1)

14 (35.9)

Poor (N = 9)

7 (77.8)

2 (22.2)

Others (N = 2)

2 (100.0)

0 (0.0)

Tumour location

Hilar (N = 36)

27 (75.0)

9 (25.0)

0.574

Peripheral (N = 25)

17 (68.0)

8 (32.0)

Tumour size

≦5 cm (N = 34)

26 (76.5)

8 (23.5)

0.566

>5 cm (N = 27)

18 (66.7)

9 (33.3)

Tumour number

Single (N = 44)

32 (72.7)

12 (27.3)

1

Multiple (N = 17)

12 (70.6)

5 (29.4)

Vascular invasiona

Positive (N = 32)

22 (68.7)

10 (31.3)

0.746

Negative (N = 16)

12 (66.7)

4 (33.3)

Serosal invasion

Positive (N = 30)

20 (77.4)

7 (22.6)

0.402

Negative (N = 31)

24 (66.7)

10 (33.3)

Lymph node metastasis

Presense (N = 23)

14 (60.9)

9 (39.1)

0.045

Absense (N = 25)

22 (88.0)

3 (12.0)

Undetermined (N = 13)

   

Distant metastasis

Presense (N = 4)

4 (100.0)

0 (0.0)

0.569

Absense (N = 57)

40 (70.2)

17 (29.8)

Preoperative

≦37 U/ml (N = 23)

18 (78.3)

5 (21.7)

0.539

Serum CA19-9

>37 U/ml (N = 29)

20 (69.0)

9 (31.0)

 

Preoperative

≦5 ng/ml (N = 38)

30 (78.9)

8 (21.1)

0.182

Serum CEA

>5 ng/ml (N = 15)

9 (60.0)

6 (40.0)

 
  1. CA19-9 carbohydrate antigen 19-9, CEA carcinoembryonic antigen MF mass forming type, PI periductal infiltrating type.
  2. a13 patients records were not available.
  3. bDifferences between continuous variables were determined using the Mann–Whitney U test. Categorical variables were compared by Fisher’s exact test.
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