Fig. 2: Survival analyses (log-rank test) of the proposed pT3a subclassification in the training cohort (Munich).

a–d Disease-specific survival analysis of pT3a vs. pT3b CRCs within all pT3 tumours (a) and in pN0 (b), pN1/2 (c) and pM0 subgroups (d) of patients with pT3 tumours. Note the significantly worse survival for pT3b CRCs, also in the specific subgroups. e–h Disease-specific survival analysis of pT3a vs. pT3b CRCs compared to all pT stages in the overall cohort (e) and in pN0 (f), pN1/2 (g) and pM0 subgroups (h). Note that pT2 and pT3a carcinomas show an almost equal survival, while pT3b CRCs show significantly worse survival characteristics that trend towards the survival of pT4a carcinomas.