Fig. 2: Putative ICI-resistant mutations in MSI-H/TMB-H and MSS/TMB-H CRCs.

a Comparison of TMB distribution between MSI-H and MSS CRCs. b Precent comparison of MSI-H and MSS composition between tumours with TMB≥10 and those with TMB < 10. c Mutations in putative ICI-resistant biomarkers in MSI-H and MSS CRCs.