Fig. 1: Study design and cohort characterisation.
From: Spatiotemporal analysis of tumour-infiltrating immune cells in biliary carcinogenesis
a A total of 139 patients with biliary tract cancer precursor lesions were included in this study: n = 65 high-grade intraductal papillary neoplasms of the biliary tract (IPNB/ITPN), n = 74 high-grade BilIN and their associated invasive and non-tumorous counterparts were selected for tissue microarray construction. Scale bars represent 100 µm. Images were acquired at ×20 magnification. b Representative immunohistochemical staining of a tissue microarray dot showing CD8+ lymphocytes in the stromal (S) and intraepithelial (E) compartments of IPNB tissue. c Kaplan–Meier survival curves of IPN- and BilIN-associated cases.
