Fig. 4: Distribution of inflammatory cell infiltrates in biliary intraepithelial neoplasia (BilIN), their associated invasive BTC (INV) and non-tumorous tissue (NT).
From: Spatiotemporal analysis of tumour-infiltrating immune cells in biliary carcinogenesis
a–d Total number of a CD4+ T lymphocytes (NT: n = 38; BilIN: n = 56; INV: n = 68), b CD8+ T lymphocytes (NT: n = 42; BilIN: n = 65; INV: n = 66), c CD20+ B lymphocytes (NT: n = 46; BilIN: n = 65; INV: n = 69) and d CD68+ macrophages (NT: n = 48; BilIN: n = 66; INV: n = 69). e Percentage of cases showing intraepithelial inflammatory cells in NT, IPN and INV. f–i Proportion per 100 biliary epithelial cells of intraepithelial, f CD4+ T lymphocytes, g CD8+ T lymphocytes, h CD20+ B lymphocytes and i CD68+ macrophages. Significant P values of Kruskal–Wallis (a–d, f–i) followed by Dunn’s post hoc analysis and Pearson’s chi-squared test (e) are shown in bold. *P < 0.05, **P < 0.01, ***P < 0.001; ns not significant, NA not applicable.
