Fig. 4: PD-1+CD8+ T cell abundance indicated T cell dysfunction. | British Journal of Cancer

Fig. 4: PD-1+CD8+ T cell abundance indicated T cell dysfunction.

From: Intratumoral PD-1+CD8+ T cells associate poor clinical outcomes and adjuvant chemotherapeutic benefit in gastric cancer

Fig. 4

a Heatmap illustrating the infiltration of CD8+ T cells with Immune-related molecules high expression by flow cytometry analysis among PD-1+CD8+ T cell infiltration and clinical stage from patients with GC (normalised by the Z-score). b The quantification of exhausted markers (CTLA-4 and TIM-3) and effector cytokines (PRF1) expression on CD8+ T cells in PD-1+CD8+ T cells high/low abundance subgroups, comparisons were also demonstrated among different TNM stages. Data were analysed by Mann–Whitney U test. Small horizontal lines indicate the mean (± SD). *P < 0.05, **P < 0.01, ***P < 0.001, ns refers to not significant. All P values presented here were two-tailed. IFN-γ interferon-γ, GZMB granzyme B, PD-1 programmed cell death protein 1, CTLA-4 cytotoxic T-lymphocyte-associated protein-4, TIM-3 T cell immunoglobulin, LAG3 lymphocyte-activation gene 3.

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