Table 1 Relationship between PD-1+CD8+ T cell infiltration and clinical characteristics.

From: Intratumoral PD-1+CD8+ T cells associate poor clinical outcomes and adjuvant chemotherapeutic benefit in gastric cancer

Factors

Discovery data set

Validation data set

PD-1+CD8+ T cells infiltration

PD-1+CD8+ T cells infiltration

Low

High

P value

Low

High

P value

All patients

105

95

 

118

123

 

Age (years)a

  

0.130

  

0.227

 Median (IQR)

61 (52–70)

59 (53–67)

 

60 (51–69)

59 (53–70)

 

Gender

  

0.521

  

0.927

 Female

32

33

 

32

34

 

 Male

73

62

 

86

89

 

Localisation

  

0.825

  

0.136

 Proximal

27

21

 

31

30

 

 Middle

16

16

 

10

21

 

 Distal

62

58

 

77

72

 

Tumour size (cm)a

  

0.908

  

0.707

 Median (IQR)

3.0 (2.0–5.0)

4.0 (3.0–5.0)

 

3.5 (2.0–4.5)

3.5 (2.0–5.0)

 

Grade

  

0.569

  

0.205

 G1

4

4

 

8

7

 

 G2

24

16

 

18

30

 

 G3&G4

77

75

 

92

86

 

Lauren classification

  

0.762

  

0.963

 Diffuse

42

40

 

39

41

 

 Intestinal

63

55

 

79

82

 

T classification

  

0.050

  

0.368

 T1

22

10

 

29

25

 

 T2

18

10

 

15

20

 

 T3

20

18

 

25

18

 

 T4

45

57

 

49

60

 

N classification

  

0.317

  

0.613

 N0

44

34

 

51

43

 

 N1

12

8

 

13

17

 

 N2

23

18

 

20

23

 

 N3

26

35

 

34

40

 

TNM stage

  

0.100

  

0.487

 I

28

14

 

39

32

 

 II

28

26

 

22

25

 

 III

49

55

 

57

66

 

Adjuvant chemotherapyb

  

0.100

  

0.035

 No

45

30

 

62

48

 

 Yes

60

65

 

56

75

 
  1. PD-1 programmed cell death protein 1, TNM tumour node metastasis.
  2. aModeled as a continuous variable.
  3. bPatients with adjuvant chemotherapy received at least one cycle of 5-fluoruracil-based chemotherapy.
  4. P value < 0.05 marked in bold font shows statistical significance.
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