Table 3 Pathways associated with top independent mammography radiomics features at diagnosis among patients with breast cancer using gene set enrichment analysisa, in tumour tissues and adjacent normal tissues.

From: Mammography radiomics features at diagnosis and progression-free survival among patients with breast cancer

    

Tumour

Normal

   

N of Genes

Direction

P*

Direction

P*

S(1,−1)SumAverg

Hallmark

G2M_CHECKPOINT

193

Up

4.99E-07

Down

0.751

 

E2F_TARGETS

198

Up

4.99E-07

Down

0.751

 

MYC_TARGETS_V1

195

Up

1.98E-04

Up

0.935

 

MYC_TARGETS_V2

58

Up

9.25E-05

Down

0.107

KEGG

DNA_REPLICATION

36

Up

8.83E-05

Down

0.947

 

MISMATCH_REPAIR

23

Up

0.023

Down

0.947

 

CELL_CYCLE

124

Up

0.043

Up

0.994

 

PROTEASOME

44

Up

0.043

Up

0.366

WavEnLL_s-6

Hallmark

G2M_CHECKPOINT

193

Up

2.81E-07

Down

0.588

 

E2F_TARGETS

198

Up

2.80E-07

Down

0.582

 

MYC_TARGETS_V1

195

Up

1.16E-04

Down

0.749

 

MYC_TARGETS_V2

58

Up

7.26E-05

Down

0.016

KEGG

DNA_REPLICATION

36

Up

2.54E-05

Down

0.889

 

MISMATCH_REPAIR

23

Up

0.011

Down

0.909

 

RIBOSOME

86

Down

0.011

Up

0.684

 

CELL_CYCLE

124

Up

0.031

Down

0.970

 

PROTEASOME

44

Up

0.041

Up

0.684

  1. N number.
  2. *FDR-corrected P-value.
  3. aThis analysis was performed in breast cancer patients whose tumours have been sequenced for RNA (n = 96) and adjusted for age, menopausal status, molecular subtype, tumour stage and histologic grade.
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