Fig. 1: PSMA expression and CD8+ T-cell infiltration in non-malignant and prostate cancer tissue samples. | British Journal of Cancer

Fig. 1: PSMA expression and CD8+ T-cell infiltration in non-malignant and prostate cancer tissue samples.

From: Identification of a high-risk immunogenic prostate cancer patient subset as candidates for T-cell engager immunotherapy and the introduction of a novel albumin-fused anti-CD3 × anti-PSMA bispecific design

Fig. 1

a PSMA expression, b CD8+ T-cell infiltration and c proportion of patients having high PSMA expression and high CD8+ T-cell infiltration (High/High) defined as >median PSMA expression and >median CD8 infiltration. N = normal, AN = adjacent normal, LPC = tumour tissue from patients with localised PC, MPC = primary tumour tissue from patients with metastatic prostate cancer. (a–b (n) = number of patients, c (n/n) = number of patients locating to Remaining/number of patients locating to High/High). PSMA expression shown using log2 fold change while CD8+ T-cell infiltration shown as cell enrichment score. d–f Spatial transcriptomics on three representative samples from the MPC cohort, with (d) corresponding to remaining subset and e, f corresponding to High/High subset, showing spatial distribution of CD8A + (red), FOLH1 + (green), and CD8A + FOLH + (blue) spots. Venn diagram depicts overlap between CD8A + and FOLH1 + spots. Statistical analysis was conducted in Rstudio (Wilcoxon test (a, b), Fisher’s exact test (c): *<0.05, **<0.01, ***<0.001, ****<0.0001, ns non-significant).

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