Fig. 2: Forest plot summarising the results of Mendelian randomisation analyses. | British Journal of Cancer

Fig. 2: Forest plot summarising the results of Mendelian randomisation analyses.

From: Disentangling the aetiological pathways between body mass index and site-specific cancer risk using tissue-partitioned Mendelian randomisation

Fig. 2

Summary of Mendelian randomisation results for BMI on 7 site-specific cancers based on (a) univariable analyses using the total set of BMI variants and (b) analyses instrumented in a multivariable setting with tissue-partitioned variants. Forest plots illustrating the odds ratios per change in risk factor and 95% confidence intervals (CIs) for each outcome analysed by MR are shown. The effect estimates of BMI instrumented with all 915 BMI SNPs is illustrated in (a) (red), and the independent effect estimates of BMI instrumented by adipose- (blue) and brain (orange)-tissue-derived instruments in the multivariable MR model are illustrated in (b).

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