Table 3 Prediction of poor disease-specific survival based on age, curettage histology, ER/PR and MMR protein expression in curettage specimens in endometrial cancer patients.

From: Mismatch repair markers in preoperative and operative endometrial cancer samples; expression concordance and prognostic value

Risk factor

N

Univariate HR (95% CI)

P

Multivariate HR (95% CI)

P

Age

394

1.1 (1.1–1.1)

<0.001

1.0 (1.02–1.1)

<0.001

Curettage histologya

 Low grade

324

1

 

1

 

 High grade

70

8.5 (5.1–14.1)

<0.001

3.6 (1.97–6.7)

<0.001

ER/PR expressionb

 High

335

1

 

1

 

 Low

59

5.7 (3.4–9.4)

<0.001

1.9 (1.02–3.4)

<0.001

MSH6

 Low

206

1

 

1

 

 High

188

4.5 (2.5–8.1)

<0.001

2.8 (1.46–5.3)

0.002

MSH2

 Low

136

1

 

1

 

 High

258

1.9 (1.1–3.5)

0.020

1.1 (0.61–2.1)

0.694

PMS2

 Low

221

1

 

1

 

 High

173

1.9 (1.2–3.1)

0.009

1.2 (0.7–2.1)

0.512

  1. MSH6 MutS Homolog 6, MSH2 MutS Homolog 2, PMS2 PMS2 Homolog 2.
  2. Statistically significant P-values (<0.05) are bold.
  3. aCurettage histological classification, low-grade (endometrioid grade 1 or 2) or high-grade (endometrioid grade 3 or non-endometrioid).
  4. bLow ER/PR expression, loss of or low expression of ER and loss of PR expression.
  5. Events: 64; Global P value (log-rank): <0.001.
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