Table 5 High MSH6 mRNA expression associates with histological subtype and molecular subgroup in the TCGA cohort.

From: Mismatch repair markers in preoperative and operative endometrial cancer samples; expression concordance and prognostic value

Variable

Low, n (%)

High, n (%)

P value

Histological subtype

  

<0.001

 Endometrioid

239 (60)

158 (40)

 

 Serous

18 (17)

91 (83)

 

 Mixed

6 (29)

15 (71)

 

Histological grade*

  

<0.001

 Grades 1–2

164 (77)

49 (23)

 

 Grade 3

75 (41)

109 (59)

 

Molecular subclass

  

<0.001

 POLE

26 (53)

23 (47)

 

 MSI

92 (62)

56 (38)

 

 CN low

109 (74)

38 (26)

 

 CN high

27 (17)

136 (83)

 
  1. POLE DNA polymerase epsilon, MSI microsatellite instable, CN copy number.
  2. Statistically significant P-values (<0.05) are bold.
  3. *Only endometrioid histology.
  4. Data missing on the histological subtype for 2 patients, the histological grade for 2 patients, and molecular subclass for 22 patients.
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