Fig. 2: Two molecular subtypes of malignant phyllodes tumours (MPTs).
From: An integrative approach for exploring the nature of fibroepithelial neoplasms
a Unsupervised clustering of nine MPT using expression levels of the top 2000 variable genes except for genes with low expression levels. b Significant pathways enriched with upregulated genes in “Group B” (top) and mRNA expression levels (FPKM) of various collagens (bottom) (Mann–Whitney test). c Significant pathways enriched with upregulated genes in “Group A” (top) and mRNA expression levels (FPKM) of epithelial cell markers such as cadherin, claudins, and occludin (bottom) (Mann–Whitney test). d Heatmaps showing the clustering of subtypes based on genes involved in cell adhesion molecules, ECM–receptor interactions, and EMT. *p < 0.05, **p < 0.01, ***p < 0.001.
