Fig. 5: RARα-Nrf2 complex activation after combined treatment with DAC and ATRA. | British Journal of Cancer

Fig. 5: RARα-Nrf2 complex activation after combined treatment with DAC and ATRA.

From: All-trans retinoic acid enhances the cytotoxic effect of decitabine on myelodysplastic syndromes and acute myeloid leukaemia by activating the RARα-Nrf2 complex

Fig. 5

Immunoprecipitation and immunoblotting indicated the formation of a RARα-Nrf2 complex in MDS-L and MOLM-13 cells treated with DAC, as a single agent or combined with ATRA. The expression level of HDAC1 binding to the complex was reduced after the combination treatment.

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