Table 1 Average discounted costs, life expectancy and ICERs for base case.
Testing policy | Average discounted costs ($) | Average life expectancy gain | Average quality-adjusted life expectancy gain | ||||
|---|---|---|---|---|---|---|---|
Years | △Days from reference policy | ICER (cost per year of life expectancy gained; $) | QALYs | △Days from reference policy | ICER (cost per year quality of life gained; $) | ||
TNBC (China) | |||||||
No gBRCA test | 25,054.75 | 14.07 | 8.32 | ||||
Selected gBRCA test | 25,738.25 | 14.15 | 31.26 | 7980.20 | 8.39 | 24.67 | 10,111.99 |
Universal gBRCA test | 26,634.18 | 14.28 | 8.47 | ||||
Refer to no test | 78.57 | 7337.09 | 54.42 | 10,592.60 | |||
Refer to selected test | 47.31 | 6912.14 | 29.75 | 10,991.12 | |||
TNBC (USA) | |||||||
No test | 79,956.71 | 14.06 | 8.32 | ||||
Selected gBRCA test | 84,279.86 | 14.16 | 34.10 | 46,267.40 | 8.39 | 26.92 | 58,632.27 |
Universal gBRCA test | 90,069.00 | 14.29 | 8.49 | ||||
Refer to no test | 81.48 | 45,297.91 | 64.30 | 57,403.03 | |||
Refer to selected test | 47.38 | 44,600.01 | 37.39 | 56,518.17 | |||
HER2-negative (China) | |||||||
No test | 22,554.50 | 16.78 | 10.31 | ||||
Selected gBRCA test | 22,720.68 | 16.87 | 30.67 | 1977.67 | 10.38 | 24.85 | 2440.46 |
Universal gBRCA test | 22,976.54 | 17.02 | 10.50 | ||||
Refer to no test | 87.63 | 1757.94 | 71.01 | 2169.32 | |||
Refer to selected test | 56.96 | 1639.62 | 46.16 | 2023.31 | |||
HER2-negative (USA) | |||||||
No test | 71,265.75 | 16.78 | 10.31 | ||||
Selected gBRCA test | 72,351.35 | 16.86 | 30.47 | 13,003.36 | 10.37 | 24.72 | 16,029.70 |
Universal gBRCA test | 74,547.72 | 17.02 | 10.51 | ||||
Refer to no test | 89.98 | 13,313.54 | 72.98 | 16,414.19 | |||
Refer to selected test | 59.51 | 13,472.37 | 48.26 | 16,611.12 | |||
