Table 2 Univariate and multiple Cox regression results for the association of baseline markers with overall survival.
Variable | Univariate | Multivariate | ||||||
|---|---|---|---|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P | |
Liver metastases present (ref no) | ||||||||
Yes | 1.78 (1.09, 2.92) | 0.022 | 2.08 (1.22, 3.54) | 0.007 | 1.98 (1.17, 3.35) | 0.011 | 2.00 (1.17, 3.42) | 0.011 |
ECOG performance status (ref 0) | ||||||||
1 | 1.66 (1.15, 2.40) | 0.007 | 1.64 (1.10, 2.46) | 0.016 | 1.67 (1.12, 2.48) | 0.011 | 1.72 (1.14, 2.58) | 0.009 |
2 | 4.15 (1.60, 10.74) | 0.003 | 1.71 (0.55, 5.28) | 0.352 | 1.74 (0.57, 5.36) | 0.332 | 1.83 (0.59, 5.65) | 0.294 |
Albumin (ref ≥ 35 g/L) | ||||||||
<35 g/L | 2.23 (1.45, 3.44) | <0.001 | 2.32 (0.89, 6.09) | 0.087 | 2.32 (0.88, 6.09) | 0.087 | 2.26 (0.86, 5.91) | 0.097 |
C-reactive protein (ref ≤ 10 mg/l) | ||||||||
>10 mg/l | 1.62 (1.13, 2.32) | 0.009 | 0.87 (0.31, 2.44) | 0.799 | 0.91 (0.33, 2.54) | 0.861 | 0.90 (0.32, 2.52) | 0.844 |
mGPS (ref 0) | ||||||||
1 | 1.37 (0.92, 2.06) | 0.123 | 1.39 (0.47, 4.14) | 0.555 | 1.33 (0.45, 3.97) | 0.605 | 1.36 (0.45, 4.05) | 0.584 |
2 | 2.46 (1.49, 4.06) | <0.001 | – | – | – | |||
Neutrophils (ref ≤ 1*ULN) | ||||||||
>1*ULN | 2.06 (1.36, 3.10) | <0.001 | 1.40 (0.87, 2.25) | 0.168 | 1.39 (0.86, 2.23) | 0.177 | 1.39 (0.86, 2.24) | 0.174 |
CA19-9 (1000) (ref ≤ 1000 U/ml) | ||||||||
>1000 U/ml | 1.18 (0.80, 1.75) | 0.401 | 1.02 (0.67, 1.56) | 0.934 | ||||
CA19-9 (200) (ref ≤ 200 U/ml) | ||||||||
>200 U/ml | 1.30 (0.81, 2.09) | 0.271 | 1.23 (0.75, 2.01) | 0.408 | ||||
CA19-9 (37) (ref ≤ 37 U/ml) | ||||||||
>37 U/ml | 1.37 (0.79, 2.38) | 0.257 | 1.29 (0.72, 2.30) | 0.397 | ||||
mutKRAS ctDNA (ref not detected) | ||||||||
Detected | 5.26 (1.63, 17.04) | 0.006 | ||||||
