Table 3 Multiple Cox regression results for the association of baseline mutKRAS ctDNA and overall survival, adjusting for different markers.
Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|
Variable | HR (95% CI) | P | HR (95% CI) | P | HR (95% CI) | P |
mutKRAS ctDNA (ref: not detected) | ||||||
Detected | 7.59 (2.22, 25.90) | 0.001 | 22.60 (3.11, 164.27) | 0.002 | 83.59 (5.71, 1223.90) | 0.001 |
Age | 1.05 (0.97, 1.14) | 0.206 | 1.05 (0.95, 1.16) | 0.352 | 1.07 (0.97, 1.19) | 0.191 |
Sex (ref: male) | ||||||
Female | 0.22 (0.07, 0.74) | 0.014 | 0.15 (0.03, 0.81) | 0.027 | 0.03 (0.00, 0.31) | 0.004 |
ECOG performance status (ref: 0) | ||||||
1 | 8.82 (2.19, 35.63) | 0.002 | 12.10 (1.66, 88.09) | 0.014 | ||
2 | 3.77 (0.70, 20.31) | 0.123 | 1.32 (0.18, 9.70) | 0.783 | ||
Liver metastases present (ref: no) | ||||||
Yes | 1.56 (0.19, 12.95) | 0.680 | 0.51 (0.05, 5.60) | 0.582 | ||
mGPS (ref: 0) | ||||||
2 | 42.34 (2.28, 785.40) | 0.012 | ||||
1 | 0.30 (0.05, 1.80) | 0.187 | ||||
CA19-9 (ref: ≤1000) | ||||||
>1000 | 1.51 (0.26, 8.65) | 0.645 | ||||
