Fig. 6: Overall impact of BCAA metabolism.
From: Convergent genomic diversity and novel BCAA metabolism in intrahepatic cholangiocarcinoma
a Immunohistochemical detection of phospho-mTOR and phospho-S6K expression in the representative FS2 case of ICC. Original magnifications: ×200 and ×400, respectively. T tumour tissue, N normal liver tissue. Quantification of the results of the immunohistochemical analyses. b Western blotting for the evaluation of p-mTOR and mTOR expression in the in normal and tumour samples of all ten cases. c Kaplan–Meier survival estimate curve for 103 cases ranked by the BCAA degradation signature.
