Fig. 2: Basal analysis of H3K27ac signal in ovarian cancer subtypes.

a Genome wide coverage of H3K27ac ChIP signal around promoter and enhancer sites in HGSC primary samples. b Counts per million of H3K27ac ChIP signal in GH19J009069 MUC16 interacting enhancer, HNF1B GH17J0377409 interacting enhancer and GH19J041709 CEACAM5 interacting enhancer in representative HGSC, CC and MC primary cells (red), cell lines (blue) and healthy samples (green). Red highlighted areas indicate the extent of enhancer regions. c, d Principal component analysis of ChIP signal in GeneHancer enhancer sites of healthy cells and ovarian cancer cell lines or primary cells. e, f Overlaps of H3K27ac peaks in replicates of UWB1.289 and GTFR230 cells. g Intersections of H3K27ac occupied GeneHancer enhancer regions for all HGSC samples analysed. See also Supplementary Fig. S1 for intersections of CC and MC samples.