Fig. 4: Identification of enriched transcription factor binding and associated complexes.

a Binding motifs identified by FIMO for top three predicted enriched TFs in enriched HGSC, CC and MC enhancer sites. b Subtype unique TFs with enriched binding in enriched enhancer sites. c MAGIC score of top ten TF binding sites for enriched GeneHancer enhancer sites in HGSC, CC and MC subtypes after filtering using MOTIF analysis and RNA-Seq expression levels. d Subtype-specific significant enrichment of TFs for the top twenty significantly enriched TFs from each subtype. e RPKM score from RNA-Seq HGSC and MC primaries for complexes only identified in HGSC and MC samples, respectively. Green borders indicate TFs identified in the pipeline and blue borders indicate complex coregulators. f Number of complexes where each coregulator is a component for HGSC samples, including only coregulators present in more than ten complexes. See also Supplementary Fig. S2 for coregulators of CC and MC samples. g E2F-1-DP-1-Cyclin A-CDK2 complex identified uniquely in HGSC. Created with BioRender.com.