Table 3 Clinical, pathological, and immunohistochemical characteristics of breast cancer patients and tumours for the subgroup with HER2-negative tumours at diagnosis, by HER2 status at recurrence (local recurrences and distant metastases together).
Parameter | Primary tumours which relapsed as HER2-low (n = 90) | Primary tumours which relapsed as HER2-negative (unchanged HER2 status) (n = 104) |
|---|---|---|
Age at diagnosis (years) | ||
Mean ± SD | 54.1 ± 11.4 | 57.3 ± 14.0 |
Median [min–max] | 55.0 [26.0–81.0] | 57.5 [26.0–89.0] |
P value | 0.075 | |
Unifocal tumour | ||
Yes | 75 (83.3%) | 85 (81.7%) |
No | 15 (16.7%) | 19 (18.3%) |
P value | 0.770 | |
Histology | ||
IDC | 65 (72.2%) | 79 (76.0%) |
ILC | 22 (24.4%) | 21 (20.2%) |
Other | 3 (3.3%) | 4 (3.8%) |
P value | 0.782 | |
Tumour size (cm) | ||
Mean ± SD | 2.2 ± 1.3 | 2.7 ± 2.2 |
Median [min–max] | 1.9 [0.4–6.5] | 2.0 [0.1–10.5] |
Missing data | 3 | 1 |
P value | 0.113 | |
E&E grade | ||
I | 20 (22.5%) | 18 (17.8%) |
II | 48 (53.9%) | 46 (45.5%) |
III | 21 (23.6%) | 37 (36.6%) |
Missing data | 1 | 3 |
P value | 0.148 | |
Glandular differentiation | ||
I | 2 (2.2%) | 3 (2.9%) |
II | 27 (30.3%) | 24 (23.5%) |
III | 60 (67.4%) | 75 (73.5%) |
Missing data | 1 | 2 |
P value | 0.577 | |
Nuclear grade | ||
I | 6 (6.7%) | 7 (6.9%) |
II | 61 (68.5%) | 60 (58.8%) |
III | 22 (24.7%) | 35 (34.3%) |
Missing data | 1 | 2 |
P value | 0.337 | |
Mitosis score | ||
I | 48 (53.9%) | 41 (40.2%) |
II–III | 41 (46.1%) | 61 (59.8%) |
Missing data | 1 | 2 |
P value | 0.080 | |
Lymph node status | ||
N0–N0i+ | 51 (56.7%) | 52 (50.0%) |
N1–N1mic | 26 (28.9%) | 34 (32.7%) |
N2–N3 | 13 (14.4%) | 18 (17.3%) |
P value | 0.645 | |
Disease stage | ||
I | 39 (39.2%) | 37 (35.6%) |
II | 31 (32.0%) | 31 (29.8%) |
III | 19 (23.7%) | 27 (26.0%) |
IV | 1 (5.2%) | 9 (8.7%) |
P value | 0.076 | |
Oestrogen receptor expression | ||
Negative | 10 (11.1%) | 27 (26.2%) |
Positive | 80 (88.9%) | 76 (73.8%) |
Missing data | 0 | 1 |
P value | 0.008 | |
Progesterone receptor expression | ||
Negative | 25 (30.9%) | 35 (35.7%) |
Positive | 56 (69.1%) | 63 (64.3%) |
Missing data | 9 | 6 |
P value | 0.494 | |
Ki67 expression | ||
Mean ± SD | 28.7 ± 19.6 | 32.8 ± 22.9 |
Median [min–max] | 25.0 [1.0–80.0] | 30.0 [1.0–90.0] |
Missing data | 66 | 78 |
P value | 0.501 | |
Time to recurrence (months) | ||
Mean ± SD | 90.3 ± 54.5 | 68.2 ± 51.9 |
Median [min–max] | 80.0 [2.0–240.0] | 53.5 [1.0–212.0] |
P value | 0.002 | |
