Table 3 Validation results, NBCSP screening outcomes compared to the model prediction of NBCSP screening outcomes.

From: The cost-effectiveness of risk-stratified breast cancer screening in the UK

Description of validation target outcomes

NBCSP screening outcomes (target outcomes)

Model prediction

Reference for target outcomes

Percentage of tumours that are DCIS at screen detection

21.1%

21.58%

Data request to the National Audit of Breast Cancer in Older Patients [24]

Invasive cancer TNM stage distribution for cancers detected by screening. Percentage in each stage

  

  Stage 1

66.00%

66.97%

  Stage 2

28.89%

27.84%

  Stage 3

4.19%

4.34%

  Stage 4

0.091%

0.85%

Size of cancers detected at screening

  Less than 20 mm (DCIS)

62.76%

55.54%

Table 1 in Mannu et al. [26]

  Above 20 mm (DCIS)

37.24%

44.46%

  Less than 20 mm (Invasive)

66.00%

56.02%

Table 2 in Breast Screening Frequency Trial Group, 2002 [27]

  Above 20 mm (Invasive)

34.00%

43.98%