Fig. 3: Urinoid UBTOR4.2 & tumoroid BTOR4.2 share high percentages of mutations with original tumour sample 4.2.

a Patient 4 treatment schedule and sampling overview for whole-genome sequencing samples. Overlap of post-treatment (4.2) organoid lines shared with or unique mutations in respect to the original tumour sample 4.2 in b SNPs, c InDels, d modifier impact mutations, e overlap of silent and missense class mutations using Mutect2 tools from the Sarek pipeline.