Fig. 2: Cumulative incidence for colorectal adenomas and post-colonoscopy CRC according to polygenic risk score (PRS).
From: Genome-wide polygenic risk scores for colorectal cancer have implications for risk-based screening
Cumulative risk of a colorectal adenomas (N = 453,733; 25,988 cases by age 80) and b 10-year incident CRC after negative colonoscopy (N = 48,951; 214 cases) by polygenic risk score (PRS) category. a Shows the cumulative risk for colorectal adenoma among individuals who had PRS in one of the following categories: less than 1%, 1–20%, 20–80%, 80–99% and above 99%. b Shows cumulative incidence for CRC among clinically average-risk individuals who underwent colonoscopy at 40 years of age or older for any indication and had PRS in one of the following categories: less than 10%, 10 to 90%, and above 90%. The shaded bands represent 95% confidence intervals. b The grey vertical bar represents the first 6 months after index colonoscopy as we only included cases diagnosed 6 months to 10 years after colonoscopy. CRC colorectal cancer.
