Fig. 1: Genomic profile of BWS-WT.
From: Cancer predisposition signaling in Beckwith-Wiedemann Syndrome drives Wilms tumor development
A Copy number alterations (CNAs) for all BWS-WT. Recurrent changes occur at the same locus in at least two samples. Gains are shown in black; losses are shown in red. B CNA for WTs relative to matched normal kidney samples as part of the tumor mutational burden. C Single nucleotide variants (SNV) for WTs relative to matched normal kidney samples as part of the tumor mutational burden. D CNA and SNV that map to known cancer-driving genes. Red represents loss or deletion; black represents gain or duplication. Light blue represents synonymous SNV, dark blue represents non-synonymous SNV, and gray represents nonsense SNV.
