Fig. 3: Differential gene expression and interactome analysis.
From: Cancer predisposition signaling in Beckwith-Wiedemann Syndrome drives Wilms tumor development
A GSEA analysis of DEGs using eVITTA (easy Visualization and Inference Toolbox for Transcriptome Analysis). B Heatmap of genes from Wnt signaling pathway, Notch signaling pathway, PPAR signaling pathway, DNA replication and cell cycle processes across BWS-WT and control kidney groups. C Protein-protein interaction network generated for genes in heatmap using STRING database. Edges connecting nodes represent functional and physical associations. D Interactome was generated using interaction output from STRING analysis which informs most interacting gene partners.
