Fig. 5: FINs sensitise cancer cells to radiotherapy in vitro and in vivo. | British Journal of Cancer

Fig. 5: FINs sensitise cancer cells to radiotherapy in vitro and in vivo.

From: GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4

Fig. 5

a–c 5-8F and CNE2 cell lines were pretreated with FIN56, sorafenib, or DMEM for 24 h before 6 Gy IR exposure. The cell viability (a), relative PTGS2 expression (b), and lipid peroxidation levels (c) were measured in the respective cell lines. d The therapeutic modality in the mice with 5-8F subcutaneously xenografted tumours. The mice with xenografts were treated with 6 Gy IR or intragastric administration of sorafenib. e–g The size (e), volume (f), and weight (g) of the xenograft tumours in control, sorafenib, IR, or combination therapy groups (n = 5). h IHC staining images of 4-HNE and PCNA of xenograft tumours from each group. Scale bars: 50 μm/20 μm. Data are presented as mean ± SEM. p values were calculated using two-tailed Student’s t test and two-way ANOVA. *p < 0.05; **p < 0.01; ***p < 0.001.

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