Fig. 6: Increased TLS maturation and treatment response with chemoimmunotherapy.
From: Synergistic induction of tertiary lymphoid structures by chemoimmunotherapy in bladder cancer
a Heatmap illustrating the characteristics of TLS maturation stages and pathological responses in patients receiving combined therapy. b Distribution of TLS positivity in baseline and post-treatment samples. c Distribution of TLS maturity in baseline and post-treatment samples. d Fold change of TLS positivity and maturity in tumors following chemotherapy, immunotherapy, and combined therapy. e Comparison of pathological complete response rates associated with neoadjuvant chemotherapy, immunotherapy, and combined therapy. f A representative case presenting a patient who developed mature TLSs after combination therapy and achieved a complete response.
