Fig. 3: scRNA-seq analysis revealed the cell ecosystem of each proteomic subtype. | British Journal of Cancer

Fig. 3: scRNA-seq analysis revealed the cell ecosystem of each proteomic subtype.

From: Integrated proteomics and scRNA-seq analyses of ovarian cancer reveal molecular subtype-associated cell landscapes and immunotherapy targets

Fig. 3

a Uniform manifold approximation and projection (UMAP) showing the distribution of 8 scRNA-seq samples. b UMAP plot showing 6 cell clusters for 8 samples analysed by 10X scRNA-seq (Left). Ratio of 6 cell types relative to the total cell count per sample (Right, the total cell count was scaled to 1). c Bubble plot showing marker genes across 6 cell clusters. Dot size indicates fraction of expressing cells, coloured according to z-score scaled to expression levels. d UMAP plot showing expression levels of selected genes. e Heatmap showing the expression signature of top marker genes for 6 cell clusters. Expression signature of differential cell type specific proteins among 4 Proteomic subtypes from Xiangya OC proteomics (f), CPTAC 2016 OC cohort (g) and 2023 OC cohort (h). Colour of each cell indicates Z score (Log2 of global protein abundance scaled to proteomic expression standard deviations) of the protein in each sample. Annotations indicate 6 cell clusters (left) and Proteomic or mRNA subtypes or gene mutation status (up).

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